New Research Into The "Golden Window" For Timing Embryo Transfer
13 October 2021
13 October 2021
With colleagues from Melbourne’s , Professor Rombauts and Provessor Vollenhoven have helped identified a Teflon-like molecule that makes the surface of the womb slippery and prevents embryos from implanting. The team also discovered that the levels of this molecule on the womb’s surface decrease at a certain point in the menstrual cycle, allowing the womb to become sticker and therefore improving the chances of implantation.
The researchers examined levels of the anti-implantation molecule, known as podocalyxin (PCX), in the endometrium of 81 women undergoing IVF treatment.
While the women with low levels of PCX had a 53% pregnancy success rate, those women where the molecule had not been reduced had a success rate of just 18%.
Measuring levels of PCX at the mid-luteal phase could in future lead to a new screening test, which could also be used to determine if someone is infertile.
The research team has already begun work to better understand the role of PCX and how it is regulated in the body, with the aim of developing infertility treatments.
PCX could be picked up through a standard pathology laboratory, making testing for it relatively cost-effective.
Professor Rombauts hope is that the team’s work will deliver a simple test that can help patients and boost the precision and personalisation of IVF treatment.
is the Medical Director of Monash IVF Group. He is a Gynaecologist and a Specialist in Reproductive Endocrinology and Infertility. He practices in Frankston, Melbourne CBD, Mornington, Clayton and Richmond in Victoria. You can book an appointment with Professor Rombauts