The Health and Fertility of Young Men Conceived Using Intra-cytoplasmic Sperm Injection (icsi)

Health and fertility of young men conceived using Intra-cytoplasmic sperm injection

Prof Jane Halliday1, Dr Sharon Lewis1, Sarah Catford2, Moira O’Bryan3, Prof Robert McLachlan2,4.

1Murdoch Children’s Research Institute, Parkville; 2Hudson Institute of Medical Research, Clayton; 3Monash University, 4Monash IVF, Clayton

The advent of Intra-Cytoplasmic Sperm Injection, or ICSI, has enabled thousands of men to become parents; yet many of these men would have been unable to father children naturally. However, the concern is that, if a man harbours a genetic mutation that causes his infertility, this mutation could be passed on to his children.

Our research aims to investigate whether children born from ICSI treatments have an increased risk of infertility or other adverse health outcomes. This project focuses specifically on young men who were conceived using ICSI in 1994-1998, and will assess their reproductive health and semen quality (therefore whether they are likely to be fertile) and will also assess their general health and development. This information will enable doctors to provide better advice to male factor infertility couples.


Recruitment for this clinical trial is ongoing.

  • This field is for validation purposes and should be left unchanged.
  • This field is for validation purposes and should be left unchanged.