Proteomic Analysis of Receptive Endometrium: Identification of Discriminative Markers

Investigators: Prof Lois Salamonsen (1), A/Prof Luk Rombauts (2,3), Dr Evdokia Dimitriadis (1), Prof David Robertson (1), Dr Guiying Nie (1), Dr Lynette Kilpatrick (1), Dr Natalie Hannan (1), Prof Jock Findlay (1)

1 Hudson Institute of Medical Research, Clayton; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Clayton

Implantation can only occur during a four day period during the mid-secretory phase of a woman’s menstrual cycle because of hormonally-induced changes in the lining of the womb (endometrium) during this window. These changes are not fully understood but we do know that they are altered in some infertile women. Furthermore, the drugs given to women during IVF treatment also change the lining of the womb. A common complaint from patients is that there are no reliable tests to reassure them that their endometrium is receptive. We hypothesise that the profile of proteins secreted into the uterine cavity will indicate the uterine receptivity. These so called ‘proteomic techniques’ are being applied to endometrial tissue and uterine fluid and a number have already been identified. We aim to develop a diagnostic test for use during infertility evaluation and to assist in modifying clinical protocols and in decision making for the clinicians.

Recruitment for this project has now completed and the results are currently being prepared for publication.

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