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Optimising Progesterone Supplementation in Frozen Embryo Transfer Cycles
Prospective randomised trial of change of progesterone dosage in HRT FETs with low serum progesterone concentrations after 2 days of treatment
When ovulation occurs in a woman, the site of ovulation in the ovary (called the corpus luteum) starts to produce progesterone. This progesterone then acts on the uterus to support the endometrium (uterine lining) and, if pregnancy occurs, supports the developing pregnancy until the placenta is developed. However, in frozen embryo transfer cycles (also known as FETs), ovulation has not occurred therefore the woman requires progesterone supplementation to support uterine function and early pregnancy development.
This research project aims to ensure that the best protocol for progesterone supplementation is used to maximise pregnancy outcomes. This study will investigate women with low serum progesterone, who are at greater risk for poorer outcomes. The study will specifically examine the effects of gradually increasing the daily progesterone dose after frozen embryo transfer and the impact on pregnancy success rates.