Optimising Progesterone Supplementation in Frozen Embryo Transfer Cycles

Prospective randomised trial of change of progesterone dosage in HRT FETs with low serum progesterone concentrations after 2 days of treatment

A/Prof Martin Healey1,2,3, Prof Beverley Vollenhoven1,4,5, Dr Surabhi K Basnayake4, Samantha Ter1

1Monash IVF, Clayton; 2Royal Women’s Hospital, Parkville; 3University of Melbourne, Parkville; 4Monash Health, Clayton; 5Monash University, Clayton.

When ovulation occurs in a woman, the site of ovulation in the ovary (called the corpus luteum) starts to produce progesterone. This progesterone then acts on the uterus to support the endometrium (uterine lining) and, if pregnancy occurs, supports the developing pregnancy until the placenta is developed. However, in frozen embryo transfer cycles (also known as FETs), ovulation has not occurred therefore the woman requires progesterone supplementation to support uterine function and early pregnancy development.

This research project aims to ensure that the best protocol for progesterone supplementation is used to maximise pregnancy outcomes. This study will investigate women with low serum progesterone, who are at greater risk for poorer outcomes. The study will specifically examine the effects of gradually increasing the daily progesterone dose after frozen embryo transfer and the impact on pregnancy success rates.

  • This field is for validation purposes and should be left unchanged.
  • This field is for validation purposes and should be left unchanged.