Over the past decade, there has been a movement towards single embryo transfers (sET) to reduce the risk of multiple births and its associated complications. Some patients mistakenly believe that the chance of pregnancy is reduced with sETs, despite reports showing that replacing an elective single embryo increases the chance of a healthy term live birth (LB) compared to double embryo transfer. This study was carried out to demonstrate that success rates with IVF have been improving despite decreasing the number of embryos transferred. This retrospective study compared LB outcomes for women who started IVF between 2001-2005 and 2006-2010. There was an average of 1.8 embryos transferred per transfer in the 2001-2005 cohort; which decreased to 1.3 in the 2006-2010 cohort. Cumulative LB rates demonstrated that the probability of a LB by cycle six was 73.7% in the 2001-2005 cohort; which increased to 88.4% by cycle six in the 2006-2010 cohort. The IVF success rate has improved despite the number of embryos transferred being reduced. This study provides further support for elective sET.
Reference: Wade JJ, MacLachlan V, Kovacs G. The success rate of IVF has significantly improved over the last decade. Aust N Z J Obstet Gynaecol. 2015 Jul 14.
The results for this project were presented at the 5th congress of the Asia Pacific Initiative on Reproduction 2014 and were published in the journal Australian and New Zealand Journal of Obstetrics and Gynaecology in 2015.