Development of a Diagnostic Test to Explore Chlamydia Trachomatis Tubal Factor Infertility in Women

Investigators: Dr Wilhelmina Huston (1), A/Prof Luk Rombauts (2,3), Dr Gareth Weston (2,3),  Dr John Allan (2), Caroline Motteram (2), Deborah de Guingand (2)

1 Queensland University of Technology, Kelvin Grove; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Clayton

Chlamydia trachomatis is a bacterium that is spread by sexual contact and it is often asymptomactic. Once it is diagnosed the infection can be easily treated with antibiotics. However, in some women the infection will result in serious damage to the upper reproductive tract. The damaged fallopian tubes are routinely diagnosed by invasive medical procedures. While there are blood tests which claim to diagnose Chlamydia related tubal infertility in women, these are not routinely used due to poor reliability of the tests. We have recently developed a highly specific blood test for women who have confirmed tubal factor infertility due to Chlamydia trachomatis. In this pilot study we showed that this blood test outperforms the other leading tests in the diagnosis of Chlamydia-associated infertility. We plan to conduct a large national observational cohort trial to evaluate the test as part of the routine infertility workup.

The results for this project were presented at the 5th congress of the Asia Pacific Initiative on Reproduction 2014. Please click on the link below for access to the publication/journal article relevant to this research study.

Reference: Memon S, Stansfield SH, Logan B, Hocking JS, Timms P, Rombauts L, Allan JA, Huston WM. Development and evaluation of a multi-antigen peptide ELISA for the diagnosis of Chlamydia trachomatis-related infertility in women. Jour Med Micro. 2016 July; 65: 915-922.

 

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