Can You Ever Collect Too Many Oocytes?

Investigators: Rosalind Briggs (1), Prof Gab Kovacs (2), Caroline Motteram (2), Vivien MacLachlan (2), Prof Gordon Baker (3)

1 Medical School, University of Edinburgh, United Kingdom; 2 Monash IVF, Clayton; 3 University of Melbourne, Carlton

The number of eggs retrieved following ovarian stimulation is often used as a surrogate outcome for clinical success. There have been several previous studies suggesting that beyond a certain number of oocytes collected the pregnancy rate in stimulated cycles with fresh embryo transfer starts to decline. This retrospective study investigated the association between the number of eggs retrieved during a stimulated cycle and clinical pregnancy and live birth outcome.

The data suggest that one cannot collect too many oocytes as both clinical pregnancy and live birth rates continue to increase as number of oocytes collected increases. Obtaining more embryos from one oocyte collection also increases the chance of cryopreservation and subsequent frozen embryo transfers and reduces the need for repeated ovarian stimulation and oocyte collections. The patient has a decreased risk of complications and a better chance of pregnancy.

The results of this study were published in the journal of Human Reproduction in 2015.

Reference: Briggs R, Kovacs G, MacLachlan V, Motteram C, Baker HW. Can you ever collect too many oocytes? Hum Reprod. 2015 Jan;30(1):81-7.

 

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