Monash IVF Research and Education Foundation

Our research projects are divided into the following categories:

The Proliferative Phase Underpins Endometrial Receptivity Failure in Female Infertility

The endometrium is the lining of the uterus, into which an embryo implants to establish pregnancy. The human endometrium is uniquely renewed each month during a menstrual cycle, which comprises three main phases, beginning with the shedding of the functional layer of the endometrium and its re-epithelialisation (the menstrual phase), followed by the regrowth and

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Human Trophectoderm-endometrial Interactions: Validating Targets to Facilitate Implantation During Ivf

During embryo implantation blastocysts appose and firmly adhere to a receptive endometrium initiating implantation: adhesion leads to implantation failure/infertility. Whilst IVF is an important intervention for infertility, implantation failure is still a critical limiting factor for IVF success: alarmingly ~ 70% of IVF embryos fail to implant. There is very little known of human blastocyst-endometrial

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Endometrial Receptivity: Validating Potential Biomarkers in the Uterine Fluid and Investigating Fundamental Biology on the Uterine Surface

Embryo culture/selection/transfer techniques have advanced greatly, yet implantation failure still poses a crucial limiting factor. It is believed that the hurdle may lay in the “soil for the seeds”, the endometrium. Currently no biochemical tests are available for endometrial receptivity, and in ART cycles embryos are transferred without knowing the status of the endometrium. Development

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Diagnostics for Endometrial Receptivity: Harnessing a Promising Biomarker and Exploiting a Non-invasive Method of Sampling

IVF has evolved into a suite of mainstream medical interventions to overcome infertility, yet implantation failure poses a critical limiting factor even when the embryos are carefully selected. This is of particular concern given that the use of IVF is increasing every year as women choose to have children at a later age. Implantation requires

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