Monash IVF Research and Education Foundation


Our research projects are divided into the following categories:


Effect of Corifollitropin-alpha on Viable Pregnancy Rate in Poor Ovarian Responders Undergoing Ivf Treatment

There is Level 1a evidence that corifollitropin-alpha (Elonva), a sustained-release gonadotropin, is a safe and equally effective alternative treatment to daily FSH injections in good prognosis patients. However, two pilot studies with Elonva in poor responders have shown no clinical benefit. In this observational study we investigated the efficacy and cost-effectiveness of corifollitropin-alpha in the

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Can You Ever Collect Too Many Oocytes?

The number of eggs retrieved following ovarian stimulation is often used as a surrogate outcome for clinical success. There have been several previous studies suggesting that beyond a certain number of oocytes collected the pregnancy rate in stimulated cycles with fresh embryo transfer starts to decline. This retrospective study investigated the association between the number

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Are Antagonist Protocols Less Optimal for Use in Satellite Ivf Clinics?

Predictability of the egg pick up (EPU) date is of great importance for patients attending satellite clinics. Predictable EPU day allows patients and clinicians to coordinate IVF treatment cycles through the satellite clinics while minimising the time and financial burden of travelling into metropolitan cities for ongoing treatment. This was a retrospective cohort analysis of

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Ivf Success Rate over the Last Decade

Over the past decade, there has been a movement towards single embryo transfers (sET) to reduce the risk of multiple births and its associated complications. Some patients mistakenly believe that the chance of pregnancy is reduced with sETs, despite reports showing that replacing an elective single embryo increases the chance of a healthy term live

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Development of a Diagnostic Test to Explore Chlamydia Trachomatis Tubal Factor Infertility in Women

Chlamydia trachomatis is a bacterium that is spread by sexual contact and it is often asymptomactic. Once it is diagnosed the infection can be easily treated with antibiotics. However, in some women the infection will result in serious damage to the upper reproductive tract. The damaged fallopian tubes are routinely diagnosed by invasive medical procedures.

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Defining the Impact of Different Assisted Reproduction Technology (art) Protocols on the Placental Epigenome

Despite the successful application of ART over the past three decades, some studies have suggested an association with an increased risk of rare imprinting disorder. The effect of ART on the placental epigenome has been the topic of lively debate in recent years, with evidence that ART may be associated with altered epigenetic status in

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Human Growth Hormone in Management of Poor Responders (the Light Study)

The ability of oocytes to form structurally normal embryos that are able to implant has been related to the concentration of hormones in ovarian follicular fluid. Growth hormone (GH) levels in blood have shown the most consistent relationship with parameters of embryo quality, with higher concentrations associated with rapid cleavage, better cleaving embryo morphology and

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Barusiban Subcutaneously for Reducing Implantation Failure Due to Uterine Contractions (the Basic Trial)

During a woman’s menstrual cycle, the muscular tissue in her womb contracts with different frequency. Contractions may also be induced when the fertilised egg(s) is transferred to the womb in women undergoing infertility treatment. Excessive contractions at the time of transferring the fertilised egg(s) have been associated with a reduced chance of pregnancy. It is

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Health Implications for Young Adults Conceived Following Assisted Reproductive Technologies

Many common adult non-communicable diseases (NCD), particularly cardiovascular, metabolic and respiratory conditions, have their origins in early life, possibly before birth. The risk trajectories track through childhood until clinical disease manifests in adulthood. Conception by assisted reproductive technologies (ART) has been suggested as adding to the risk profile for a range of adult onset NCD,

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Combined Adjuvant Therapy in Ivf-icsi

Over the past two decades, IVF has seen significant improvements, leading to much improved outcomes for many infertile couples. Nevertheless, a significant proportion of couples still experience the distress of repeated failure to conceive. A history of repeated IVF failure presents a formidable challenge to the fertility specialist offering clinical guidance. By the time patients

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Melatonin and Infertility: Can We Improve Outcomes of Assisted Reproductive Technology – a Randomised Placebo Controlled Trial

During ART, eggs and embryos may interact negatively with oxygen molecules in a process called ‘oxidative stress’. In recent years, interest has gathered regarding the role of oxidative stress on the quality of stored eggs and embryos, potentially reducing success rates and live birth rates following ART. It is proposed that melatonin, a potent antioxidant,

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