Investigators: Dr Lufee Wong1, A/Prof Fabricio da Silva Costa1, Dr Simon Meagher1
1 Monash IVF, Clayton
During pregnancy, the inner layers of the womb (endometrium and junctional zone (JZ) undergo specialized changes to facilitate the implantation of the placenta. Disruptions to this process can cause pregnancy problems. Adenomyosis, a condition which can disrupt the JZ, is one of these conditions, and can potentially affect the ability to fall pregnant (fertility) as well as pregnancy outcomes. More recently, magnetic resonance imaging (MRI) is used to better define this layer. Even more recently, 3-dimensional (3D) ultrasound has been used to describe these conditions. It has made it possible to define and assess the JZ in comparison with 2D ultrasound. To assess the JZ, a new classification has been described recently. The aim of this study is to examine (i) how assessment of the JZ by the same operator and different operators differ (if any at all) and (ii) to examine the relationship between these JZ irregularities and pregnancy rates in IVF cycles.
Recruitment for this clinical trial is ongoing, and is available for patients at Clayton clinics.