Investigators: Prof Jane Halliday 1, Dr Sharon Lewis 1, Sarah Catford2, Moira O’Bryan3,Prof Robert McLachlan2,4.
1 Murdoch Childrens Research Institute, Parkville; 2Hudson Institute of Medical Research, Clayton; 3Monash University, 4Monash IVF, Clayton
Male infertility has important health consequences for the man and offspring. The male germ line plays a crucial role in determining the genetic and epigenetic composition of offspring and therefore their subsequent long-term health. Our main aim is to evaluate the physical and psychological health, educational and social development, and fertility status of young men who were conceived using ICSI at Monash IVF for fathers with severe infertility and compare them to young men conceived using ICSI at Monash IVF for previously fertile fathers. Our primary research question is whether there is a difference in overall health between these two groups. We hypothesise that ICSI-conceived young men of fathers with severe will have poorer physical health outcomes and indices of fertility through genetic and epigenetic changes influencing growth and development, chronic disease and spermatogenesis.
Recruitment for this clinical trial is ongoing