Completed Projects - Monash IVF

Monash IVF Research and Education Foundation

The early work of our pioneers that resulted in the World’s First IVF Pregnancy in 1973 has been an ongoing driver for our commitment to continued scientific and clinical innovation. As testament to this commitment stands our long history of investing in clinical research and evidenced-based care.

Below are some examples of the exceptional and leading research completed by the MREF which highlights the importance that Monash IVF places on research and the ability of effectively and efficiently translating research into treatments that can benefit our patients.

Our research projects are divided into the following categories:

Health Implications for Young Adults Conceived Following Assisted Reproductive Technologies

This large cohort study compares the long term safety outcomes for young adults conceived by assisted reproductive technology (ART) with non-ART-conceived young adults. Continue reading

Barusiban Subcutaneously for Reducing Implantation Failure Due to Uterine Contractions (The BASIC trial)

A randomised placebo-controlled trial assessing the effect of barusiban, a selective oxytocin antagonist, on implantation and pregnancy rates. Administered on the day of embryo transfer, Barusiban is able to reduce the frequency of uterine contractions and thereby increase the likelihood of implantation. Continue reading

Human Growth Hormone in management of poor responders (The LIGHT Study)

A randomised placebo-controlled trial seeking to address the question of whether human growth hormone administered to patients, who have not responded well in a previous IVF cycle, improves the chance of pregnancy and livebirth in a subsequent cycle. Continue reading

Risk of placenta previa in ART births linked to endometrial thickness in Singleton births

A retrospective study investigating the association between endometrial combined thickness (ECT) in ART cycles and the relative risk of placenta praevia. Continue reading

Proteomic analysis of receptive endometrium: identification of discriminative markers

A cohort study investigating the profile of proteins secreted into the uterine cavity to identify markers for uterine receptivity in order to develop a diagnostic test for use during infertility evaluation. Continue reading

Defining the impact of different assisted reproduction technology (ART) protocols on the placental epigenome

The first genome-wide study into the effects of different ART protocols on placental epigenetics. It is anticipated that the findings of this study will lead to therapeutic interventions that eliminate any adverse effects ART may have on the epigenetic status of both the placenta and child. Continue reading

Oocyte vitrification: IVF and pregnancy outcomes at Monash IVF

This case-controlled study investigated the utilisation of frozen oocytes in IVF and consequent pregnancy outcomes from fresh and vitrification oocyte thaw cycles. Oocyte vitrification appears to be a viable option for many patients, providing good pregnancy and birth outcomes. Continue reading

Development of a diagnostic test to explore Chlamydia trachomatis tubal factor infertility in women

In this pilot study we demonstrate that our recently developed highly specific blood test for Chlamydia trachomatis outperforms the other leading tests in the diagnosis of Chlamydia-associated infertility. Continue reading

A multi-clinic prospective study of participants engaging in a Victorian altruistic surrogacy program

This prospective study investigated the experiences of the commissioning couple and the surrogate and her partner at the beginning stages of entering into a surrogacy program, and at key stages throughout the arrangement. Continue reading

IVF success rate over the last decade

This retrospective study compared live birth outcomes for women who started IVF between 2001 and 2005 with women who started between 2006 and 2010. The IVF success rate has significantly improved despite the average number of embryos transferred being reduced. Continue reading

Are Antagonist Protocols Less Optimal for use in Satellite IVF Clinics?

A retrospective analysis of agonist and antagonist treatment cycles conducted at satellite clinics showed that antagonist cycles have a higher proportion of patient’s with egg collection outside the established collection window which requires transfer to metropolitan clinics for collection. Continue reading

Can you ever collect too many oocytes?

This retrospective study investigated the association between the number of eggs retrieved during a stimulated cycle and clinical pregnancy and live birth outcome. Continue reading

Effect of Corifollitropin-alpha on viable pregnancy rate in poor ovarian responders undergoing IVF treatment

An observational study investigating the efficacy and cost-effectiveness of corifollitropin-alpha (ELONVA) among poor ovarian responders undergoing IVF treatment. Continue reading

Utilisation of ART in Single Women and Lesbian couples since the 2010 change in Victorian legislation

This retrospective cohort study observed trends in ART use amongst single women and lesbian couples prior to and following the change in legislation in January 2010 which allowed these individuals access to reproductive treatments. Continue reading

Decisions about confirmatory prenatal testing following preimplantation genetic diagnosis

This study surveyed couples who had a baby born following Preimplantation genetic diagnosis (PGD) to determine if they proceeded with confirmatory prenatal tests (PNT) as recommended and their reasons for doing so. Continue reading

Incidence and zygosity of twin births following transfers using a single fresh or frozen embryo

A retrospective cohort analysis of fresh and frozen IVF/ICSI cycles involving single embryo transfer (SET) was conducted to estimate the monozygotic and dizygotic twinning rates. A large majority of twin births following a SET in a frozen cycle were discordant presumably due to a concurrent naturally conceived pregnancy. Continue reading

Combined adjuvant therapy in IVF-ICSI

This case-controlled study investigated whether combined adjuvant treatment improves live birth rates in fresh and frozen cycles. We found no benefit of this combined adjuvant strategy in fresh IVF cycles, and possible harm when used in frozen cycles. Continue reading

Is Fresh Best?

In this case controlled study we sought to determine whether a ‘freeze only’ strategy in IVF compromises cumulative pregnancy rates. The pregnancy rates achieved in freeze only cycles were no different to those seen in fresh embryo transfer cycles. Continue reading

The Proliferative Phase Underpins Endometrial Receptivity Failure in Female Infertility

This study investigates proliferative phase endometrial developmental disturbance associated with unexplained female infertility. It is anticipated this will lead to the identification of molecules/pathways for development of future therapeutic approaches to improve endometrial quality in infertile women. Continue reading

Melatonin and infertility: Can we improve outcomes of assisted reproductive technology – a randomised placebo controlled trial

This randomised placebo controlled trial investigates whether melatonin supplementation can improve IVF success rates by reducing the harmful effects of oxidative stress on eggs and embryos. Continue reading

Appointment Confirmation