Monash IVF Research and Education Foundation

Monash IVF Research and Education Foundation

Monash IVF recognises the benefits of conducting original research and of undertaking dynamic educational programs to maintain its leading position in reproductive medicine, and to fulfil its social duty to improve healthcare. In 2010 the Monash IVF Board of Directors approved the creation of the Monash IVF Research and Education Foundation (MREF), operating under an Advisory Board of clinical, scientific and educational specialists to advise on ways in which Monash IVF could produce internationally-recognised research, to provide educational programs for professionals and to raise community awareness and knowledge in reproductive medicine.

The 2015 MREF Annual Report is now available for download.

Below are some examples of the exceptional and leading research that are being carried out by the MREF which highlights the importance that Monash IVF places on research and the ability of effectively and efficiently translating research into treatments that can benefit our patients.

Our research projects are divided into the following categories:

Three dimensional ultrasound of the junctional zone in myometrial pathology and their correlation with pregnancy rates

Investigators: Dr Lufee Wong1, A/Prof Fabricio da Silva Costa1, Dr Simon Meagher1 1 Monash IVF, Clayton During pregnancy, the inner layers of the womb (endometrium and junctional zone (JZ) undergo specialized changes to facilitate the implantation of the placenta... Continue reading

Health and fertility of young men conceived using Intra-cytoplasmic sperm injection

Investigators: Prof Jane Halliday 1, Dr Sharon Lewis 1, Sarah Catford2, Moira O’Bryan3,Prof Robert McLachlan2,4. 1 Murdoch Childrens Research Institute, Parkville; 2Hudson Institute of Medical Research, Clayton; 3Monash University, 4Monash IVF, Clayton Male infe... Continue reading

The effects of unrecognised Chlamydial infection on sperm production in human infertility

Investigators: A/Prof Ken Beagley 1, Dr Danica Hickey 1, Emily Bryan 1, Prof Eileen MacLaughlin 2, Prof Rob McLachlan 3, A/Prof Luk Rombauts 3,4, Caroline Motteram 3, Dr Darren Katz 5 1 Queensland University of Technology, Brisbane; 2 University of Newcastle, Calla... Continue reading

Non-invasive prenatal testing with cell-free DNA for fetal trisomies 21, 18 and 13, in an ART population

Investigators: Dr Fabricio Costa (1), Andrew McLennan (2), Dr Simon Meagher (1), Dr Melody Menezes (1), Prof Jon Hyett (3) 1 Monash Ultrasound for Women, Clayton; 2 Sydney Ultrasound for Women, Burwood; 3 Royal Prince Alfred Hospital, Sydney ART pregnancies have re... Continue reading

Studies on the genetic basis of male and idiopathic infertility, and the trans-generational health of children conceived through ART

Investigators: A/Prof Moira O’Bryan (1), Dr Liza O’Donnell (2,3), Prof Robert McLachlan (3,4), Dr Duangporn Jamsai (1), Prof Andrew Sinclair (5); Dr Alicia Oshlack (5) 1 Dept. Anatomy and Developmental Biology, Monash University; 2 Monash Institute of Medic... Continue reading

The establishment of a normal range of embryonic heart rates in IVF pregnancies at seven weeks’ gestation in an Australian population: embryonic heart rate as a determinant of first trimester loss

Investigators: Presanna Sujenthiran (1), Dr Martha Finn (1), Dr Simon Meagher (1), Paul Lombardo (2) 1 Monash Ultrasound for Women, Richmond; 2 Dept. Medical Imaging and Radiation Sciences, Monash University ART births now account for ~3.6% of Australian births wi... Continue reading

A survey of cancer survivors who stored reproductive material at Monash IVF

Investigators: Professor Jane Fisher (1), Dr Karin Hammarberg (1), Dr Maggie Kirkman (1), Prof Robert McLachlan (2,3), A/Prof Luk Rombauts (3,4), Prof. Beverley Vollenhoven (3,4) 1 Jean Hailes Research Unit, Monash University, Clayton; 2 Hudson Institute of Medical... Continue reading

Fertility Understanding through Registry and Evaluation (FUTuRE Fertility)

Investigators: Dr Antoinette Anazodo (1), Professor Elizabeth Sullivan (2), Prof Robert McLachlan (3,4), A/Prof Luk Rombauts (4,5) 1 Sydney Children Hospital, Randick; 2 Women’s and Children’s Health, Randick; 3 Hudson Institute of Medical Research, Clayton; 4 ... Continue reading

The Proliferative Phase Underpins Endometrial Receptivity Failure in Female Infertility

Investigators: Harriet Fitzgerald1,2, Prof Lois Salamonsen1,2, Prof Luk Rombauts1,2,3, A/Prof Beverly Vollenhoven1,2,3, Dr. Tracey Edgell1,4 1Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton;  2Department of Obstetrics and Gynaecology... Continue reading

Role of Endometrial Stem/Progenitor Cells in the Endometrial Injury Effect on ART Outcomes: the Fourth Hypothesis

Investigators: A/Prof Beverley Vollenhoven (2) A/Prof Caroline Gargett (1), Germana Ryan (1), A/ Prof Luk Rombauts (2,3), Dr Gareth Weston (2,3)  1 Hudson Institute of Medical Research, Clayton; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Cl... Continue reading

Podocalyxin may represent a major barrier for endometrial receptivity

Investigators: A/Professor Guiying Nie (1), Dr Sarah Paule (1), A/Prof Luk Rombauts (2,3), A/Prof Beverley Vollenhoven (2,3) 1 Hudson Institute of Medical Research, Clayton; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Clayton Assisted reproduc... Continue reading

Developing a non-invasive screening tool for Aneuploidy

Investigators: Dr Eva Dimitriadis (1), A/Prof Luk Rombauts (2,3), Dr Tiki Osianlis (3) 1 Hudson Institute of Medical Research, Clayton; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Clayton Human oocytes display a high degree of aneuploidy and t... Continue reading

Endometrial thickness and its association with uterine hyper-peristalsis in IVF

Investigators: Dr Michelle Dunn (1), A/Prof Luk Rombauts (1,2), Caroline Motteram (2), Dr Shavi Fernando (1) 1 Monash Dept Obstetrics and Gynaecology, Clayton; 2 Monash IVF, Clayton There is some evidence that the thickness of the endometrium may be associated wit... Continue reading

Diagnostics for Endometrial Receptivity: harnessing a promising biomarker and exploiting a non-invasive method of sampling

Investigators: A/Prof Guiying Nie (1), A/Prof Luk Rombauts (2,3), A/Prof Beverley Vollenhoven (2,3) 1 Hudson Institute of Medical Research, Clayton; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Clayton IVF has evolved into a suite of mainstream... Continue reading

Endometrial receptivity: validating potential biomarkers in the uterine fluid and investigating fundamental biology on the uterine surface

Investigators: A/Prof Guiying Nie (1), A/Prof Luk Rombauts (2,3), A/Prof Beverley Vollenhoven (2,3) 1 Hudson Institute of Medical Research, Clayton; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Clayton.  Embryo culture/selection/transfer techni... Continue reading

Human trophectoderm-endometrial interactions: validating targets to facilitate implantation during IVF

Investigators: A/Prof Eva Dimitriadis (1), A/Prof Luk Rombauts (2,3), Dr Tiki Osianlis(3) 1 Hudson Institute of Medical Research, Clayton; 2 Monash IVF, Clayton; 3 Monash Dept Obstetrics and Gynaecology, Clayton During embryo implantation blastocysts appose and fir... Continue reading

PeTALS: A longitudinal study exploring women’s experiences following a prenatal diagnosis of fetal abnormality

Investigators: Dr Melody Menezes (1), Professor Sylvia Metcalfe (2), Dr Jan Hodgson (2), Professor Jane Fisher (3), A/Prof Kerry Petersen (4), A/Prof Jane Halliday (2)  1 Monash Ultrasound for Women, Richmond; 2 Murdoch Children’s Research Institute, Parkville;... Continue reading